Filmed on location in different locations surrounding Mexico City, Señora Acero tells the story of Sara Aguilar Bermúdez (Blanca Soto), a beautiful, charismatic and intelligent woman who goes from being a housewife with an ordinary life to a person capable of shaking the very foundations of her country’s government.
After the shocking murder of her husband, Vicente Acero, Sara learns that he was not the man she thought he was. From that moment on, Sara and her son must run for their lives to evade the authorities and Victor’s enemies.